drugset

drugset / Trial / NCT04773717

The Effect of High Dose Parenteral Ascorbic Acid On Microcirculation In Sepsis

NCT04773717 ↗

Completed 60 enrolled Lithuanian University of Health Sciences

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to evaluate the effect of high-dose ascorbic acid on microcirculation in sepsis.

Timeline

Start: 2019-01-01
Primary completion: 2021-01-31
Completion: 2021-01-31

Publications

Belousoviene E, Pranskuniene Z, Vaitkaitiene E, Pilvinis V, Pranskunas A. Effect of high-dose intravenous ascorbic acid on microcirculation and endothelial glycocalyx during sepsis and septic shock: a double-blind, randomized, placebo-controlled study. BMC Anesthesiol. 2023 Sep 12;23(1):309. doi: 10.1186/s12871-023-02265-z.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Vitamin C	Other / unclassified	50 mg/kg	Intravenous

Indications