The Impact of Prednisone on Semen Parameters and Pregnancy Rates Post Vasectomy Reversal

Phase 4 Active not recruiting 100 enrolled Charitable Union for the Research and Education of Peyronie's Disease

RandomizedParallel-groupOpen-labelTreatment

Summary

1. Determine impact of prednisone on semen parameters post vasectomy reversal (evaluated both using prednisone as a combined cohort as well as via 3 separate protocols). 2. Determine impact of prednisone on pregnancy rates post vasectomy reversal (evaluated both using prednisone as a combined cohort as well as via 3 separate protocols). 3. Assess adverse events with prednisone utilization

Timeline

Start: 2021-02-24
Primary completion: 2026-02
Completion: 2026-02

Publications

Trost L, Helo S, Brearton K, Warner R, Ziegelmann M, Kohler T, Savage J. Impact of prednisone on vasectomy reversal outcomes (iPRED study): results from a randomized, controlled clinical trial. Fertil Steril. 2025 May;123(5):804-811. doi: 10.1016/j.fertnstert.2024.11.019. Epub 2024 Nov 20.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Prednisone	Other / unclassified	5 mg	—

Indications

No indication recorded.