Per Oral Versus Intravenous Postoperative Antibiotics After Surgery for Complicated Appendicitis.

Summary

The PIPA trial is a prospective, multicentre, cluster randomized cluster crossover non-inferiority study. We aim to test whether a three-day postoperative course of per oral antibiotics is non-inferior to a three-day postoperative course of intravenous antibiotics as standard care after laparoscopic surgery for complicated appendicitis in regards to the risk of postoperative intraabdominal abscess formation within 30-days

Timeline

Start

2021-04-01

Primary completion

2024-05-31

Completion

2024-06-30

Publications

• Mohamud AA, Zeyghami W, Kleif J, Gogenur I. Postoperative recovery in peroral versus intravenous antibiotic treatment following laparoscopic appendectomy for complicated appendicitis: a substudy of a cluster randomized cluster crossover non-inferiority study. Langenbecks Arch Surg. 2024 Oct 9;409(1):303. doi: 10.1007/s00423-024-03491-w.

Drugs

Indications