drugset / Trial / NCT04803539

A Prospective, Phase II Trial Using ctDNA to Initiate Post-operation Boost Therapy After Adjuvant Chemotherapy in TNBC

NCT04803539

RandomizedParallel-groupOpen-labelTreatment

Summary

Circulating tumor DNA (ctDNA) has been demonstrated to be an effective prognostic marker in breast cancer. Various studies have shown that early TNBC breast cancer patients with positive ctDNA have high risk of cancer recurrence and worse prognosis. This study aimed to identify TNBC patients with positive ctDNA and initiate boost therapy in these high risk patients.

Timeline

Start
2021-04-01
Primary completion
2028-09-01
Completion
2033-09-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Camrelizumab Monoclonal antibody 200 mg Intravenous
Subject Capecitabine Small molecule 650 mg/m2 Oral
Subject Rivoceranib Small molecule 250 mg Oral

Indications