SAD/MAD Safety and PK Study of QPX9003 (Novel Polymyxin) in Normal Healthy Volunteers

Summary

The worldwide spread of resistance to antibiotics among gram-negative bacteria, particularly members of the ESKAPE group of pathogens, has resulted in a crisis in the treatment of hospital acquired infections. In particular, the presence of multi-drug resistant Acinetobacter baumannii and Pseudomonas aeruginosa in hospitals around the world poses a considerable threat. .

Timeline

Start

2021-06-03

Primary completion

2022-07-14

Completion

2022-07-14

Publications

• Watkins M, Zhu Y, Griffith DC, Loutit JS, Margolis D, Gu P. Phase 1 study of the safety, tolerability, and pharmacokinetics of a synthetic macrocyclic peptide antibiotic (BRII-693) in healthy adult participants. Antimicrob Agents Chemother. 2025 Jan 31;69(1):e0128824. doi: 10.1128/aac.01288-24. Epub 2024 Dec 9.

Drugs

Indications