Effect of N-803 on B Cell Follicles in Antiretroviral Treated HIV Disease

Summary

N-803 has demonstrated ability to reactivate HIV from latency and can activate T cells and NK cells to clear those cells, thus reducing the reservoir. However, a concern is that CD8 T cells may be excluded from the B cell follicles, where a significant part of the reservoir resides. Webb, et al, has shown that in SIV infected monkeys CD8 T cells in follicles increase in frequency when N-803 is administered. We hypothesize that in HIV infected humans treated with N-803 that CD8 T cells will increase in B cell follicles and that there will be a further reduction in the frequency of cells with an inducible provirus.

Timeline

Start

2021-04-01

Primary completion

2022-07-18

Completion

2023-01-01

Publications

• Rhein J, Chipman JG, Beilman GJ, Cromarty R, Escandon K, Anderson J, Wieking G, Reichel J, Batres R, Khoruts A, Basting CM, Hinderlie P, Davis ZB, Eaton A, Vaughn BP, Eilkhani E, Safrit JT, Soon-Shiong P, Baker JV, Klatt NR, Deeks SG, Miller JS, Schacker TW. Impact of the IL-15 superagonist N-803 on lymphatic reservoirs of HIV. JCI Insight. 2025 Jun 3;10(13):e190831. doi: 10.1172/jci.insight.190831. eCollection 2025 Jul 8.

Drugs

Indications