drugset / Trial / NCT04816487

Effect of Glutathione vs KI in Reducing SDF Staining When Used in Treatment of Primary Carious Teeth

NCT04816487

Unknown 60 enrolled Cairo University
RandomizedParallel-groupDouble-blindTreatment

Summary

Although black staining is considered a drawback that is clinically observed following SDF application and is the main primary barrier for its use clinically . Child's behaviour and cooperation cannot be controlled at a young age or in special health care needs cases. Therefore, the best treatment modality will always be a simple, fast and painless procedure and SDF is the best solution for those cases. Discolouration caused researchers to search for a solution that will reduce or prevent discolouration using KI and GSH. A systematic review was conducted in-vitro, and it showed the use of SDF with KI had reduced stains markedly, potential advantages of minimal staining might be advantageous, along a short period. However, studies with long-term follow-up would be required to provide evidence-based guidelines for using SDF and KI formulations in routine clinical practice

Timeline

Start
2021-05-01
Primary completion
2021-08-01
Completion
2022-05-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Glutathione Peptide
Subject potassium iodide Unknown