Dupilumab Effect on Pruritus Neuro-mechanisms in Patients With Atopic Dermatitis

Summary

Primary Objective: \- Assess change in neuronal architecture following long term treatment with dupilumab in skin biopsies from atopic dermatitis (AD) participants with chronic pruritus. Secondary Objectives: * Assess change in neuronal architecture following short term treatment with dupilumab and during follow-up in skin biopsies from AD participants with chronic pruritus. * To evaluate the efficacy of dupilumab in AD participants with chronic pruritus. * To evaluate the safety of dupilumab in adult participants with moderate-to-severe AD.

Timeline

Start

2021-04-22

Primary completion

2022-06-30

Completion

2022-08-30

Drugs

Indications