drugset / Trial / NCT04826679

Neoadjuvant Camrelizumab in Combination With Cisplatin and Nab-paclitaxel in Resectable HNSCC

NCT04826679 ↗

NaSingle-groupOpen-labelTreatment

Summary

This study is a single arm phase II trial including 53 patients with T2N2-3M0、T3-4N0-3M0(III-IV) head and neck squamous cell carcinoma (HNSCC) eligible for resection, who receive neo-adjvuant Camrelizumab combined with cisplatin and Nab-paclitaxel. This proposed study will evaluate the efficacy and safety of preoperative administration of Camrelizumab combined with chemotherapy in Head and Neck Squamous Cell Carcinoma (HNSCC) who are about to undergo surgery.

Timeline

Start
2021-04-01
Primary completion
2023-04-01
Completion
2026-04-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Camrelizumab Monoclonal antibody 200 mg Intravenous
Subject Cisplatin Other / unclassified 60 mg/m2 Intravenous
Subject Nab-paclitaxel Small molecule 260 mg/m2 Intravenous