Ketamine Low dOse Evaluation on Morphine Consumption in Traumatic Patient

Phase 3 Completed 140 enrolled Assistance Publique Hopitaux De Marseille

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The aim of this study is to demonstrate a significant reduction of at least 25% in opioid consumption at 48 hours of management of severe trauma, while demonstrating non-inferiority in terms of analgesia, in a group of patients receiving a continuous infusion of low dose ketamine compared to a placebo group.

Timeline

Start: 2022-08-05
Primary completion: 2025-10-04
Completion: 2026-01-03

Publications

Duclos G, Resseguier N, Arbelot C, Pastene B, Zieleskiewicz L, Leone M. Ketamine Low dOse Evaluation on morphine consumption in traumatic patients: study protocol for a randomized, double-blind, placebo-controlled trial (KLOE-Trial). Scand J Trauma Resusc Emerg Med. 2026 Jun 17. doi: 10.1186/s13049-026-01649-7. Online ahead of print.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketamine	Small molecule	0.15 mg/kg	Intravenous

Indications

No indication recorded.