drugset

drugset / Trial / NCT04834206

Nedaplatin in Treatment for Nasopharyngeal Carcinoma

NCT04834206 ↗

Phase 2 Completed 32 enrolled Affiliated Cancer Hospital & Institute of Guangzhou Medical University

NaSingle-groupOpen-labelTreatment

Summary

To evaluate the efficacy of induction chemotherapy with nedaplatin, docetaxel and 5-Fluorouracil followed by concurrent nedaplatin combined with radical radiotherapy in locally advanced nasopharyngeal carcinoma.

Timeline

Start: 2021-05-01
Primary completion: 2021-10-29
Completion: 2022-05-01

Publications

Chen FZ, Deng Y, Yin WJ, Wang MY, Yang F, Yang ZH, Zhou LP, Chen SD, Chen JL, Jiang XZ, Zhou AX, Ou YM, Liu JQ, Chen DP, Qi B. Induction chemotherapy with nedaplatin, docetaxel and 5-fluorouracil followed by concurrent nedaplatin and radiotherapy in locoregionally advanced nasopharyngeal carcinoma: A single arm, open label, phase II clinical trial. Transl Oncol. 2026 Feb;64:102634. doi: 10.1016/j.tranon.2025.102634. Epub 2026 Jan 6.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Docetaxel	Small molecule	60 mg/m2	Intravenous
Subject	Nedaplatin	Small molecule	100 mg/m2	Intravenous
Subject	fluorouracil	Small molecule	3000 mg/m2	Intravenous

Indications