The Efficacy of Stabilized Chlorine Dioxide Rinse as a Chemical Adjuvant for Treatment of Per-implant Mucositis
Summary
A full understanding of etiology and diagnosis of peri-implant diseases is crucial for finding effective treatments for these diseases that are more widely accessible to dentists. Several treatment protocols for peri-implant diseases have been proposed, but no gold standard has been established to date. Thus, the purpose of this study is to analyze efficacy of stabilized chlorine dioxide as a chemical adjuvant for treatment of peri-implant mucositis in a non-surgical treatment protocol with a 3-month follow-up.
Timeline
- Start
- 2018-03-15
- Primary completion
- 2020-01-15
- Completion
- 2020-03-04
Outcome
Mixed primary results
registry MEAN Test - Stabilized Chlorine Dioxide Rinse: 2.37 (Standard Error 0.166) mm NCT04838054 ↗
registry MEAN Placebo - Oral Rinse, no Active Ingredients: 2.64 (Standard Error 0.130) mm NCT04838054 ↗
registry p = 0.28 NCT04838054 ↗
registry MEAN Test - Stabilized Chlorine Dioxide Rinse: 1.57 (Standard Error 0.110) score on a scale NCT04838054 ↗
registry MEAN Placebo - Oral Rinse, no Active Ingredients: 1.98 (Standard Error 0.110) score on a scale NCT04838054 ↗
registry p = 0.011 NCT04838054 ↗
registry MEAN Test - Stabilized Chlorine Dioxide Rinse: 1.48 (Standard Error 0.025) score on a scale NCT04838054 ↗
registry MEAN Placebo - Oral Rinse, no Active Ingredients: 1.52 (Standard Error 0.035) score on a scale NCT04838054 ↗
registry p <0.001 NCT04838054 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | stabilized chlorine dioxide | Unknown | — | Oral |