drugset / Trial / NCT04838678
Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)
Non-randomizedParallel-groupOpen-labelBasic science
Summary
The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.
Timeline
- Start
- 2021-07-18
- Primary completion
- 2026-08-31
- Completion
- 2026-08-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Neuropeptide Y | Peptide | — | Other |