Effects of a Seven-day BASIS™ Supplementation on Menopausal Syndromes and Measurements of the Urinary Vitamin B3 and Estradiol Levels in Pre-, Peri- and Post-menopause

Summary

The purpose of this study is to determine whether a short supplementation (7days) with BASIS™ increases the natural production of estradiol, measured in urinary waste. The overall objective is to determine whether through increased estradiol levels, the undesirable menopausal effects, assessed via questionnaires, are mitigated by a short-term supplementation with BASIS™

Timeline

Start

2021-04-05

Primary completion

2021-07-15

Completion

2021-07-15

Publications

• Results Parazzini F. Resveratrol, tryptophanum, glycine and vitamin E: a nutraceutical approach to sleep disturbance and irritability in peri- and post-menopause. Minerva Ginecol. 2015 Feb;67(1):1-5.
• Results Uberti F, Morsanuto V, Aprile S, Ghirlanda S, Stoppa I, Cochis A, Grosa G, Rimondini L, Molinari C. Biological effects of combined resveratrol and vitamin D3 on ovarian tissue. J Ovarian Res. 2017 Sep 15;10(1):61. doi: 10.1186/s13048-017-0357-9.
• Results Davinelli S, Scapagnini G, Marzatico F, Nobile V, Ferrara N, Corbi G. Influence of equol and resveratrol supplementation on health-related quality of life in menopausal women: A randomized, placebo-controlled study. Maturitas. 2017 Feb;96:77-83. doi: 10.1016/j.maturitas.2016.11.016. Epub 2016 Nov 27.
• Results Leo L, Surico D, Deambrogio F, Scatuzzi A, Marzullo P, Tinelli R, Molinari C, Surico N. [Preliminary data on the effectiveness of resveratrol in a new formulation in treatment of hot flushes]. Minerva Ginecol. 2015 Oct;67(5):475-83. Italian.
• Results Narumi M, Takahashi K, Yamatani H, Seino M, Yamanouchi K, Ohta T, Takahashi T, Kurachi H, Nagase S. Oxidative Stress in the Visceral Fat Is Elevated in Postmenopausal Women with Gynecologic Cancer. J Womens Health (Larchmt). 2018 Jan;27(1):99-106. doi: 10.1089/jwh.2016.6301. Epub 2017 Aug 17.
• Results Murugesan K, Vij U, Lal B, Farooq A. Effect of progestins, estradiol, and coenzymes NAD and NADPH on the interconversion of estradiol and estrone in rabbit uterus in vitro. Steroids. 1989 Jun;53(6):695-712. doi: 10.1016/0039-128x(89)90061-5.
• Results Yaku K, Okabe K, Nakagawa T. NAD metabolism: Implications in aging and longevity. Ageing Res Rev. 2018 Nov;47:1-17. doi: 10.1016/j.arr.2018.05.006. Epub 2018 Jun 5.
• Results Bonkowski MS, Sinclair DA. Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds. Nat Rev Mol Cell Biol. 2016 Nov;17(11):679-690. doi: 10.1038/nrm.2016.93. Epub 2016 Aug 24.
• Results Joffe H, Petrillo LF, Koukopoulos A, Viguera AC, Hirschberg A, Nonacs R, Somley B, Pasciullo E, White DP, Hall JE, Cohen LS. Increased estradiol and improved sleep, but not hot flashes, predict enhanced mood during the menopausal transition. J Clin Endocrinol Metab. 2011 Jul;96(7):E1044-54. doi: 10.1210/jc.2010-2503. Epub 2011 Apr 27.
• Holmes HE, Srivastava K, Scalici JM, Dhuguru J, Shea AE, Migaud ME, Dellinger RW. Nicotinamide riboside and pterostilbene reduces frequency and severity of undesirable symptoms of the menopause transition: an open-label, pilot clinical trial. Front Aging. 2026 May 13;7:1773667. doi: 10.3389/fragi.2026.1773667. eCollection 2026.

Drugs

Indications

No indication recorded.