Effects of Tradipitant on Satiation, Gastric Volume, Gastric Accommodation, and Gastric Emptying in Healthy Volunteers

Phase 1/2 Completed 27 enrolled Vanda Pharmaceuticals Mayo Clinic · collab

RandomizedParallel-groupQuadruple-blindBasic science

Summary

To evaluate the effects of tradipitant relative to placebo on satiation, gastric volume, gastric accommodation, and gastric emptying in healthy volunteers.

Timeline

Start: 2021-02-01
Primary completion: 2021-09-24
Completion: 2021-09-24

Publications

Khanna L, Zheng T, Atieh J, Torres M, Busciglio I, Carlin JL, Xiao M, Harmsen WS, Camilleri M. Clinical trial: a single-centre, randomised, controlled trial of tradipitant on satiation, gastric functions, and serum drug levels in healthy volunteers. Aliment Pharmacol Ther. 2022 Jul;56(2):224-230. doi: 10.1111/apt.17065. Epub 2022 May 29.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Tradipitant	Small molecule	85 mg	Oral

Indications

No indication recorded.