drugset / Trial / NCT04852185
Evaluation of Typhoid Conjugate Vaccine Effectiveness in Ghana
Phase 4
Unknown
23000 enrolled
International Vaccine Institute
Fondation Mérieux · collabInternational Centre for Diarrhoeal Disease Research, Bangladesh · collabKwame Nkrumah University of Science and Technology · collabUniversity of Cambridge · collabUniversity of Maryland, Baltimore · collab
RandomizedParallel-groupQuadruple-blindPrevention
Summary
A cluster-randomised controlled Phase IV trial (cRCT) assessing the impact of a Vi-Polysaccharide conjugate vaccine in preventing typhoid infection in Asante Akim, Ghana (TyVEGHA) with a primary endpoint of determining the total protection conferred by single-dose vaccination with Vi-TT against blood culture-confirmed symptomatic S. Typhi infection in the intervention vaccine clusters, compared with the control vaccine clusters.
Timeline
- Start
- 2021-08-24
- Primary completion
- 2024-12-31
- Completion
- 2024-12-31