GI Permeability Change in Response to Aquamin®

Summary

This trial is being completed to learn about how Aquamin® affects gastrointestinal permeability, or the control of material passing from inside the gastrointestinal tract through the gut wall into the rest of the body, in people with ulcerative colitis (UC), Irritable Bowel Syndrome with diarrhea (IBS-D), and in healthy individuals.

Timeline

Start

2021-11-02

Primary completion

2024-03-11

Completion

2024-03-25

Outcome

Met primary endpoint

paper Overall, Aquamin ® supplementation reduced total post-intervention mannitol excretion by 29% (p = 0.024). PMID 41646788 ↗

paper the reduction at the 0-2 h interval reached statistical significance (p = 0.015). PMID 41646788 ↗

Publications

• Results Aslam MN, Turgeon DK, Appelman HD, Stidham R, McClintock S, Allen R, Moraga G, Harber I, Jencks KJ, McNeely MM, Sen A, Jepsen KJ, Varani J. A multi-mineral intervention to improve disease-related and mechanistic biomarkers in ulcerative colitis patients: Results from a randomized trial. PLoS One. 2025 Dec 8;20(12):e0337408. doi: 10.1371/journal.pone.0337408. eCollection 2025.
• Results Aslam MN, Turgeon DK, McClintock S, Allen R, Sen A, Varani J. A Multi-Mineral Intervention Improves Intestinal Permeability in Patients with Ulcerative Colitis: Results from a 90-Day Pilot Trial. medRxiv [Preprint]. 2026 Jan 30:2026.01.28.26345064. doi: 10.64898/2026.01.28.26345064.
• Aslam MN, Turgeon DK, McClintock S, Allen R, Sen A, Varani J. A multi-mineral intervention is associated with improved intestinal permeability in patients with ulcerative colitis: results from a pilot trial. Front Med (Lausanne). 2026 Jun 22;13:1805900. doi: 10.3389/fmed.2026.1805900. eCollection 2026.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Aquamin	Other / unclassified	800 mg	—

Indications