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drugset / Trial / NCT04860505

Combo-PEP: Multipurpose Prevention of Post-Exposure Prophylaxis Regimens

NCT04860505 ↗

Phase 4 Completed 20 enrolled Emory University Centers for Disease Control and Prevention · collab

NaSingle-groupOpen-labelPrevention

Summary

The study will determine tissue pharmacology of a single dose of doxycycline for sexually transmitted infection (STI) Post-exposure Prophylaxis (PEP).

Timeline

Start: 2021-05-20
Primary completion: 2022-05-09
Completion: 2022-05-09

Publications

Daly MB, Spandau M, Edwards TE, Dinh C, Fountain J, Dienhart JA, Conway-Washington C, Kelley C, Heneine W, Haaland R. Chelating anticoagulants reduce plasma doxycycline measurements: implications for doxy PEP monitoring. Expert Rev Clin Pharmacol. 2026 Jan-Feb;19(2):199-205. doi: 10.1080/17512433.2026.2632931. Epub 2026 Feb 19.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Biktarvy	Other / unclassified	200 mg	Oral
Subject	Doxycycline	Small molecule	200 mg	Oral

Indications