The Synapse Project
Summary
The overarching goal of this project is to use \[C-11\]UCB-J to obtain spatial information on neuronal synapse abundance and inform Alzheimer's disease (AD) progression. The investigators propose to collect longitudinal amyloid, tau, and Synaptic vesicle glycoprotein 2A (SV2A) positron emission tomography (PET) in participants in the Wisconsin Alzheimer's Disease Research Center (ADRC) and Wisconsin Registry for Alzheimer's Prevention (WRAP) across the clinical stages of AD, including cognitively unimpaired biomarker negative, unimpaired biomarker positive, mild cognitive impairment (MCI), and dementia due to AD.
Timeline
- Start
- 2018-11-18
- Primary completion
- 2023-10-17
- Completion
- 2025-05-01
Outcome
Missed primary endpoint
registry analysis (superiority test); Medial Temporal Lobe UCB-J vs Hippocampal Volume; p = .74; DeLong's Test NCT04871074 ↗
registry analysis (superiority test); Medial Temporal Lobe UCB-J vs Hippocampal Cingulum NDI; p = .66; DeLong's Test NCT04871074 ↗
registry analysis (superiority test); All Participants; p = .135; Mixed Models Analysis NCT04871074 ↗
registry analysis (superiority test); Cognitively Unimpaired; p = .39; Mixed Models Analysis NCT04871074 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | APP-311 | Diagnostic / imaging agent | — | — |