drugset / Trial / NCT04874480

Tegavivint for the Treatment of Relapsed or Refractory Leukemia

NCT04874480

Phase 1 Active not recruiting 9 enrolled M.D. Anderson Cancer Center
NaSingle-groupOpen-labelTreatment

Summary

This phase I trial is to find out the best dose and side effects of tegavivint in treating patients with leukemia that has come back (relapsed) or does not response to treatment (refractory). Tegavivint may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving tegavivint in combination with decitabine may help control the disease.

Timeline

Start
2021-09-27
Primary completion
2027-02-02
Completion
2027-02-02

Drugs

EvaluationDrugModalityDoseRoute
Subject Decitabine Small molecule Intravenous
Subject Tegavivint Small molecule Intravenous

Indications