drugset / Trial / NCT04875702
Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout
Phase 4
Recruiting
650 enrolled
Massachusetts General Hospital
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) · collab
RandomizedParallel-groupDouble-blindTreatment
Summary
The TRUST study is a randomized, controlled multicenter study to evaluate the management of gout by comparing two commonly used treatment strategies for gout (TTT vs TTASx) to determine the most beneficial for a patient-centered gout outcomes, as well as relevant cardiovascular-metabolic-renal endpoints.
Timeline
- Start
- 2024-02-22
- Primary completion
- 2028-09-01
- Completion
- 2028-10-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Allopurinol | Small molecule | 800 mg | — |
| Comparator | Colchicine | Small molecule | 0.6 mg | Oral |
| Comparator | Colchicine | Small molecule | 1.2 mg | Oral |
| Comparator | Naproxen | Small molecule | 250 mg | Oral |
| Comparator | Naproxen | Small molecule | 500 mg | Oral |
| Comparator | Prednisone | Other / unclassified | 40 mg | Oral |