drugset / Trial / NCT04884594
AAV8-hCocH for Cocaine Use Disorder
Phase 1
Active not recruiting
10 enrolled
W. Michael Hooten
National Institute on Drug Abuse (NIDA) · collab
Non-randomizedSequentialOpen-labelOther
Summary
The purpose of this study is to test the safety of a novel gene viral vector treatment for adults with cocaine use disorder-sustained remission. This gene regulates an enzyme (cocaine hydrolase) that breaks down cocaine into inactive substances, thereby decreasing the pleasurable feeling this drug usually provides.
Timeline
- Start
- 2021-10-08
- Primary completion
- 2026-12
- Completion
- 2026-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | AAV8-hCocH | Unknown | 2e+12 vg/kg | Intravenous |
| Subject | AAV8-hCocH | Unknown | 4e+12 vg/kg | Intravenous |
| Subject | AAV8-hCocH | Unknown | 6e+12 vg/kg | Intravenous |