drugset / Trial / NCT04908176
A Drug-drug Interaction Study of Avapritinib and Midazolam
NaSingle-groupOpen-labelOther
Summary
The purpose of this study is to investigate the effect of multiple dosing of avapritinib on the pharmacokinetics (PK) of midazolam in adult patients with metastatic or unresectable gastrointestinal stromal tumors (GIST), recurrent gliomas, or other KIT mutant tumors.
Timeline
- Start
- 2022-08-24
- Primary completion
- 2024-03-01
- Completion
- 2024-05-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Avapritinib | Small molecule | 300 mg | Oral |
| Subject | Midazolam | Small molecule | 5 mg | Oral |