drugset / Trial / NCT04909255
Beta-3 Agonist and Anti-muscarinic Agent for Sjogren's Syndrome With Overactive Bladder
RandomizedParallel-groupOpen-labelTreatment
Summary
Overactive bladder is more prevalent among the Sjogren syndrome's population compare to the general population. Both anti-muscarinic agent and beta-3 agonist are recommended as second line treatment for overactive bladder syndrome. However, theoretically, undesirable effect of the anti-muscarinic agent such as dry mouth and constipation would make it less suitable for Sjogren syndrome patient with overactive bladder. Therefore, this study is a randomised control study with the aim to evaluate the therapeutic effect of beta-3 agonist and anti-muscarinic agent on overactive bladder among sjogren's syndrome patient.
Timeline
- Start
- 2021-03-23
- Primary completion
- 2022-08-15
- Completion
- 2022-08-15
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Mirabegron | Other / unclassified | — | — |
| Comparator | Oxybutynin | Small molecule | — | — |
| Comparator | Solifenacin | Small molecule | — | — |
| Comparator | Tolterodine | Small molecule | — | — |