drugset / Trial / NCT04909255

Beta-3 Agonist and Anti-muscarinic Agent for Sjogren's Syndrome With Overactive Bladder

NCT04909255

Phase 4 Unknown 50 enrolled China Medical University Hospital
RandomizedParallel-groupOpen-labelTreatment

Summary

Overactive bladder is more prevalent among the Sjogren syndrome's population compare to the general population. Both anti-muscarinic agent and beta-3 agonist are recommended as second line treatment for overactive bladder syndrome. However, theoretically, undesirable effect of the anti-muscarinic agent such as dry mouth and constipation would make it less suitable for Sjogren syndrome patient with overactive bladder. Therefore, this study is a randomised control study with the aim to evaluate the therapeutic effect of beta-3 agonist and anti-muscarinic agent on overactive bladder among sjogren's syndrome patient.

Timeline

Start
2021-03-23
Primary completion
2022-08-15
Completion
2022-08-15

Drugs

EvaluationDrugModalityDoseRoute
Subject Mirabegron Other / unclassified
Comparator Oxybutynin Small molecule
Comparator Solifenacin Small molecule
Comparator Tolterodine Small molecule