drugset
drugset / Trial / NCT04911543

A Study to Investigate the Regional Brain Kinetics of the Positron Emission Tomography Ligand [18F]-JNJ-70099731 in Healthy Male Participants

NCT04911543 ↗

Phase 1 Completed 13 enrolled Janssen Research & Development, LLC
Non-randomizedSequentialOpen-labelBasic science

Summary

The purposes of this study are to measure the whole-body distribution and radiation dosimetry of \[18F\]-JNJ-70099731 (Part A), to measure the uptake, distribution, and clearance (CL) of \[18F\]-JNJ-70099731 by Positron Emission Tomography (PET) and to model tissue specific kinetics of \[18F\]-JNJ-70099731 with the appropriate input function (IF) (Part B), and to measure participant test-retest variability in the distribution of \[18F\]-JNJ-70099731 by comparing PET scans obtained at least 1 week apart (Part C) in the brain of healthy male participants.

Timeline

Start
2021-06-23
Primary completion
2022-02-01
Completion
2022-02-01

Drugs

EvaluationDrugModalityDoseRoute
Subject [18F]-JNJ-70099731 Diagnostic / imaging agent — Intravenous

Indications

No indication recorded.