Use of Exhaled Particles to Assess Lung Pharmacokinetics

Completed 6 enrolled Fraunhofer-Institute of Toxicology and Experimental Medicine AstraZeneca · collab

RandomizedCrossoverOpen-labelBasic science

Summary

This research project in humans aims at increasing the general understanding of lung pharmakokinetic by sampling exhaled particles. The central hypothesis of this study is that pharmacokinetics of Salbutamol (model drug) can be monitored in exhaled particles.

Timeline

Start: 2021-06-14
Primary completion: 2021-08-03
Completion: 2021-08-03

Publications

Background Schwarz K, Biller H, Windt H, Koch W, Hohlfeld JM. Characterization of exhaled particles from the healthy human lung--a systematic analysis in relation to pulmonary function variables. J Aerosol Med Pulm Drug Deliv. 2010 Dec;23(6):371-9. doi: 10.1089/jamp.2009.0809. Epub 2010 May 25.
Background Schwarz K, Biller H, Windt H, Koch W, Hohlfeld JM. Characterization of exhaled particles from the human lungs in airway obstruction. J Aerosol Med Pulm Drug Deliv. 2015 Feb;28(1):52-8. doi: 10.1089/jamp.2013.1104. Epub 2014 Jun 10.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Salbutamol	Unknown	400 ug	Inhaled
Subject	Salbutamol	Unknown	8 mg	Inhaled

Indications

No indication recorded.