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drugset / Trial / NCT04920539

In Vivo Study of THC-induced Immune-genome Changes at Single Cell Solution in HIV-infected Humans

NCT04920539 ↗

Phase 1 Completed 56 enrolled Yale University National Institute on Drug Abuse (NIDA) · collab
NaSingle-groupOpen-labelOther

Summary

In this study, the investigators hypothesize that THC alters the immunogenome in a cell type-specific fashion and alters cytokine production via epigenetic regulatory mechanisms and that these alterations differ between HIV-infected and HIV-uninfected host genomes.

Timeline

Start
2022-02-08
Primary completion
2025-12-01
Completion
2025-12-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Dronabinol Other / unclassified 0.03 mg/kg Intravenous

Indications

HIV infectious disease