Obese Human Beta-2-adrenergic Stimulation and Muscle Glucose Uptake

Summary

The purpose of this study is to investigate the effect of four weeks clenbuterol/placebo supplementation on skeletal muscle glucose disposal in overweight/obese male and (postmenopausal) female volunteers.

Timeline

Start

2022-08-16

Primary completion

2024-03-01

Completion

2024-03-01

Outcome

Missed primary endpoint

paper Insulin-stimulated glucose uptake tended to improve in vastus lateralis (15%, p = 0.072) PMID 42014715 ↗

Publications

• Van Lier PMG, van de Weijer T, Vanweert F, Brouwers K, Nijssen KMR, Schaart G, Moonen-Kornips E, van Beek SMM, Springer S, Wierts R, Joris PJ, Schrauwen-Hinderling VB, Phielix E, Bengtsson T, Schrauwen P, Hoeks J. Prolonged beta2-agonist treatment enhances muscle-specific glucose uptake in individuals with overweight and obesity: a randomized placebo-controlled trial. Nat Commun. 2026 Apr 21;17(1):5483. doi: 10.1038/s41467-026-71897-9.

Drugs

Indications