11C-YJH08 PET Imaging for Detection of Glucocorticoid Receptor Expression

Summary

This phase I trial studies if positron emission tomography (PET) imaging using 11C-YJH08 can be useful for detecting certain cell receptor expression in tumor cells in patients with cancer that has spread to other parts of the body (metastatic). 11C-YJH08 is a small-molecule radiotracer that binds to receptors on cells (glucocorticoid receptor) so that they show up better on the PET scan. Systemic therapy (including enzalutamide) can cause more glucocorticoid receptors to be produced in tumor cells, which can make the tumor cells resist hormone therapies. If researchers can find a better way to detect whether glucocorticoid receptors are increasing during therapy, it may lead to more successful therapies using glucocorticoid receptor antagonists.

Timeline

Start

2021-08-10

Primary completion

2025-02-28

Completion

2025-02-28

Outcome

Outcome not reported

Stopped (Enrollment): “Slow accrual”

Drugs

Indications