drugset / Trial / NCT04933864
COVID-19 Treatment Using Methylene Blue and Photodynamic Therapy
Phase 1
Completed
60 enrolled
I.M. Sechenov First Moscow State Medical University
Prokhorov General Physics Institute of the Russian Academy of Sciences (GPI RAS) · collab
RandomizedParallel-groupSingle-blindTreatment
Summary
According to the epidemiological situation worldwide and the number of vaccinations made, there is little success in the fight against COVID-19. For many reasons, methylene blue is a promising drug for an active treatment against SARS-CoV-2 infected patients. Since methylene blue can work as a photosensitizer, photodynamic therapy as an antiviral treatment has great potential in the treatment of COVID-19. This clinical study investigated the effectiveness of SARS-CoV-2 infected people treatment using methylene blue and the following photodynamic therapy on the base of the L.L. Levshin Institute of Cluster Oncology (Department of Infectious Diseases №13) of I.M. Sechenov First Moscow State Medical University.
Timeline
- Start
- 2020-04-24
- Primary completion
- 2020-05-20
- Completion
- 2020-07-30
Publications
- Background Strakhovskaya, M. G., Meerovich, G. A., Kuskov, A. N., Gonchukov, S. A., & Loschenov, V. B. (2020, September 1). Photoinactivation of coronaviruses: Going along the optical spectrum. Laser Physics Letters. IOP Publishing Ltd. https://doi.org/10.1088/1612-202X/abab14
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Methylene Blue | Diagnostic / imaging agent | 0.2 mg | Oral |
| Subject | Methylene Blue | Diagnostic / imaging agent | 1 mg/kg | Oral |