drugset / Trial / NCT04947059

Effectiveness of an Immediate Postoperative Intravesical Instillation With Either Gemcitabine or Epirubicin in Patients With Urinary Bladder Cancer (Gemcitabine Epirubicin Normal SAline)

NCT04947059

Phase 3 Recruiting 180 enrolled University of Thessaly
RandomizedParallel-groupTriple-blindPrevention

Summary

The natural history of non-muscle-invasive bladder cancer is characterised by recurrence and progression. We compare the effectiveness of gemcitabine hydrochloride and epirubicin hydrochloride, in combination with continuous saline irrigation, as an immediate single intravesical instillation in the potential reduction of the disease recurrence as well as progression.

Timeline

Start
2021-12-14
Primary completion
2025-10
Completion
2026-10

Drugs

EvaluationDrugModalityDoseRoute
Comparator Epirubicin Small molecule 50 mg Intrathecal
Comparator Gemcitabine Small molecule 2 g Intrathecal