Induction of Transplant Tolerance in LDLT Via iTS

Phase 1/2 Unknown 10 enrolled Juntendo University Junten Bio Co., Ltd. · collab

NaSingle-groupOpen-labelTreatment

Summary

The purpose of this clinical trial is to examine the immunotolerance-inducing ability (effectiveness) of induced inhibitory T cells JB-101 in patients with living-donor liver transplantation using "whether or not operational tolerance is achieved" as an index. And the safety of JB-101 will be evaluated.

Timeline

Start: 2020-12-15
Primary completion: 2026-02-28
Completion: 2026-02-28

Publications

Results Todo S, Yamashita K, Goto R, Zaitsu M, Nagatsu A, Oura T, Watanabe M, Aoyagi T, Suzuki T, Shimamura T, Kamiyama T, Sato N, Sugita J, Hatanaka K, Bashuda H, Habu S, Demetris AJ, Okumura K. A pilot study of operational tolerance with a regulatory T-cell-based cell therapy in living donor liver transplantation. Hepatology. 2016 Aug;64(2):632-43. doi: 10.1002/hep.28459. Epub 2016 Mar 10.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	JB-101	Unknown	—	—

Indications

No indication recorded.