drugset / Trial / NCT04955145

Evaluation of The Effect of Rutin and Vitamin C on the Oxidative Stress in Hemodialysis Patients

NCT04955145

Phase 3 Unknown 105 enrolled Ain Shams University
RandomizedParallel-groupOpen-labelTreatment

Summary

The aim of the study is to evaluate the effect of rutin and vitamin C on selected oxidative stress and inflammatory markrers. Patients will be recruited according to the inclusion and exclusion criteria and will be divided into 3 groups, Group 1: Patients will administer a combination of Vitamin C and Rutin (RUTA C 60 tablets) in a dose of 2 tablets 3 times daily for 4 months in addition to their standard therapy, Group 2: will administer vitamin C 500mg hard gelatin capsules (twice daily) in addition to their standard therapy for a period of 4 months, Group3 (Control group) will administer the standard therapy. Blood samples will be withdrawn for measurement of; MDA, TNF-α ,GSH-PX, C-RP levels and ESR.

Timeline

Start
2021-06-20
Primary completion
2022-01
Completion
2022-02

Drugs

EvaluationDrugModalityDoseRoute
Comparator Rutin Unknown 120 mg
Comparator Vitamin C Other / unclassified 320 mg
Comparator Vitamin C Other / unclassified 500 mg