Endoscopic Assisted Calcium Electroporation in Esophageal Cancer

Summary

In this pilot study, patients with non-curable esophageal cancer will be treated with endoscopic assisted calcium electroporation (CaEP). CaEP is a novel cancer treatment where intratumoral injection with calcium is combined with locally applied electrical pulses, in order to increase calcium influx which leads to tumor necrosis. It is hypothesized that: * Endoscopic assisted CaEP is a safe and feasible procedure in patients with non-curable esophageal cancer * CaEP debulks the tumor, facilitating the patient's ability to eat and drink In this single-arm pilot study, eight patients will be treated.

Timeline

Start

2021-05-25

Primary completion

2022-06-13

Completion

2022-06-13

Publications

• Egeland C, Baeksgaard L, Gehl J, Gogenur I, Achiam MP. Palliative Treatment of Esophageal Cancer Using Calcium Electroporation. Cancers (Basel). 2022 Oct 27;14(21):5283. doi: 10.3390/cancers14215283.

Drugs

Indications