Naldebain and Video-assisted Thoracoscopic Surgery

Phase 4 Unknown 60 enrolled Kaohsiung Medical University Chung-Ho Memorial Hospital

RandomizedParallel-groupQuadruple-blindTreatment

Summary

To evaluate the postoperative analgesic effect of combined use of Naldebain® and thoracic paravertebral block in thoracoscopic surgery

Timeline

Start: 2021-07-07
Primary completion: 2024-05-07
Completion: 2024-05-07

Outcome

Met primary endpoint

paper The mean fentanyl consumption over three days was significantly lower in the DS group (283 ± 70 µg) compared to the placebo group (708 ± 190 µg, P < 0.001). PMID 40382572 ↗

Publications

Hsu HT, Ma CW, Chang PC, Kuo YW, Gau TP, Liu YW, Liu YC, Chou SH, Cheng KI. Effect of Dinalbuphine sebacate on postoperative multimodal analgesic strategy in video-assisted thoracoscopic surgery: a double-blind randomized controlled trial. BMC Anesthesiol. 2025 May 17;25(1):252. doi: 10.1186/s12871-025-03118-7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dinalbuphine sebacate	Small molecule	150 mg	Intramuscular

Indications

No indication recorded.