drugset / Trial / NCT04973345
Terbutaline Sulfate in Adults With Asthma
RandomizedCrossoverTriple-blindTreatment
Summary
The overall aim in Part 1 is to compare the pharmacokinetic (PK)/pharmacodynamics (PD) relationship in intravenous (IV) versus subcutaneous (SQ) terbutaline sulfate to identify the optimal IV dosing range for use in Part 2. The overall aim in Part 2 is to evaluate the optimal IV dosing of terbutaline sulfate based on PD response and safety data.
Timeline
- Start
- 2023-07-07
- Primary completion
- 2026-12
- Completion
- 2026-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Terbutaline | Small molecule | 0.1 mg | Intravenous |
| Subject | Terbutaline | Small molecule | 0.25 mg | Intravenous |
| Subject | Terbutaline | Small molecule | 0.5 mg | Intravenous |
| Subject | Terbutaline | Small molecule | 1 mg | Intravenous |