drugset / Trial / NCT04981704
A Study to Evaluate the Effect of Multiple Doses of Itraconazole, Phenytoin, and Paroxetine on the Single-Dose Pharmacokinetics of Poziotinib in Healthy Adult Participants
Non-randomizedSequentialOpen-labelBasic science
Summary
The purpose of the study is to evaluate the effect of multiple-doses of itraconazole, phenytoin and paroxetine on the single-dose pharmacokinetics (PK) of poziotinib in healthy adult participants.
Timeline
- Start
- 2021-04-08
- Primary completion
- 2021-06-30
- Completion
- 2021-08-17
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Itraconazole | Small molecule | 200 mg | Oral |
| Subject | Paroxetine | Small molecule | 20 mg | Oral |
| Subject | Phenytoin | Unknown | 100 mg | Oral |
| Subject | Poziotinib | Small molecule | 8 mg | Oral |
| Subject | Poziotinib | Small molecule | 16 mg | Oral |
Indications
No indication recorded.