Spirulina Platensis for PPI Withdrawal

Summary

Background: Rebound acid hypersecretion after proton pump inhibitors (PPIs) discontinuation may be accompanied by dyspepsia. Aim: To assess whether Spirulina platensis, by its anti-inflammatory properties, could minimize rebound symptoms after PPIs withdrawal.

Timeline

Start

2010-11

Primary completion

2012-02

Completion

2012-02

Outcome

Mixed primary results

paper A two-month course of Spirulina platensis was able to attenuate rebound dyspepsia but not reflux symptoms after PPI discontinuation. PMID 38401078 ↗

paper Rebound dyspepsia occurred in 10 out of 18 patients treated with spirulina (55.56%) and in 22 out of 25 patients treated with placebo (88%) PMID 38401078 ↗

paper with relative risk=0.63, CI95% (0.41-0.98), and P = .039. PMID 38401078 ↗

paper Reflux symptoms postintervention occurred in 72% and 76%, with the relative risk=0.95, CI95% (0.66-1.36), and P > .05, respectively. PMID 38401078 ↗

Publications

• Gronevalt ATM, Bertolin TE, Forcelini CM, Polletto PHM, Pasetti BW, Graeff DB, Rodriguez R, Fornari F. Spirulina Platensis Attenuates Rebound Dyspeptic Symptoms After Proton Pump Inhibitors' Discontinuation: Phase 2 Placebo-controlled Trial. Altern Ther Health Med. 2024 Feb;30(2):18-24.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Spirulina platensis	Unknown	530 mg	Oral

Indications