A Phase 2a Study of TPN-101 in Patients With Progressive Supranuclear Palsy (PSP)

Summary

This is a Phase 2a study to assess the safety and tolerability of TPN-101 patients with PSP.

Timeline

Start

2021-12-12

Primary completion

2024-02-24

Completion

2024-03-24

Publications

• Nicodemus J, Liu CS, Ransom L, Tan V, Romanow W, Jimenez N, Chun J. Sequence Diversity and Encoded Enzymatic Differences of Monocistronic L1 ORF2 mRNA Variants in the Aged Normal and Alzheimer's Disease Brain. J Neurosci. 2025 Jun 18;45(25):e2298242025. doi: 10.1523/JNEUROSCI.2298-24.2025.

Drugs

Indications