drugset / Trial / NCT05045950

Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique

NCT05045950

Phase 2 Recruiting 53 enrolled Medical College of Wisconsin
NaSingle-groupOpen-labelTreatment

Summary

Study patients will receive Whole-brain radiation therapy (WBRT) - pulsed reduced dose rate (PRDR) within 14 days of registration. All patients will receive single daily fractions using 3D conformal radiotherapy. A dose of 30 Gy in 10 fractions will be delivered using the PRDR technique.

Timeline

Start
2021-11-17
Primary completion
2028-05
Completion
2029-05

Drugs

EvaluationDrugModalityDoseRoute
Background Memantine Unknown 20 mg Oral
Background Memantine Unknown 28 mg Oral