drugset / Trial / NCT05075980

Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT Study

NCT05075980 ↗

Phase 2 Active not recruiting 174 enrolled Mayo Clinic
Non-randomizedParallel-groupOpen-labelTreatment

Summary

This clinical trial studies how well intensity modulated proton therapy (IMPT) or intensity modulated X-ray (radiation) therapy (IMRT) works after surgery in treating patients with head and neck cancer. IMPT is a type of radiation therapy that allows for the most accurate application of proton radiation to the tumor and has the potential to reduce treatment-related side effects. IMRT is a type of 3-dimensional radiation therapy that uses computer-generated images to show the size and shape of the tumor. Thin beams of x-ray radiation of different intensities are aimed at the tumor from many angles. This type of radiation therapy reduces the damage to healthy tissue near the tumor. IMPT may work as well as IMRT after surgery in treating patients with head and neck cancer.

Timeline

Start
2022-02-16
Primary completion
2028-02-05
Completion
2031-03-05

Drugs

EvaluationDrugModalityDoseRoute
Background Cisplatin Other / unclassified — Intravenous