Reconsolidation Therapy With Propranolol as a Treatment for Chronic Pain

Summary

The primary aim of this study is to document the feasibility and acceptability of an intervention consisting of pain neuroscience education and reconsolidation therapy with propranolol in adults suffering from chronic pain (chronic low back pain or fibromyalgia). The secondary aim of the study is to estimate the effect size of the intervention on pain and function one month post-intervention, and to obtain data for sample-size calculation for a subsequent randomized controlled trial.

Timeline

Start

2022-02-07

Primary completion

2024-12-30

Completion

2025-08-31

Publications

• Coulombe-Leveque A, Lafrenaye S, Brunet A, Morin M, Marchand S, Leonard G. Reconsolidation blockade with propranolol as a novel treatment for fibromyalgia: a double-blind, randomized placebo-controlled feasibility study. J Pain. 2026 Jul 10:106375. doi: 10.1016/j.jpain.2026.106375. Online ahead of print.

Drugs

Indications