Duloxetine RCT on Postop TKA Outcomes

Summary

The aim of this study is to determine if duloxetine is associated with differences in post-operative pain, patient-reported outcome measures, and opioid consumption in patients undergoing primary total knee arthroplasty compared to patients who do not receive the medication. If so, duloxetine has the potential to become widely incorporated into the multi-modal analgesic regimen given to patients following knee replacements.

Timeline

Start

2021-11-01

Primary completion

2025-06-01

Completion

2025-07-23

Drugs

Indications