Effect of Autologous Cord Blood-mononuclear Cells Infusion on Immune Microenvironment in Infants Born Very Preterm in NICU

Summary

Multi-omics (analysis of peripheral blood immune cells subset, peripheral blood MNCs transcriptome, soluble inflammatory cytokine profile in blood and airway secretion, lung and gut microbiota, and the interaction) analysis was used to profile immune alternation of infants with intravenous ACBMNC infusion in very preterm monozygotic twins

Timeline

Start

2021-11-28

Primary completion

2022-08-18

Completion

2022-08-18

Publications

• Ren Z, Nie C, Xu F, Gao W, Yang S, Han J, Wei W, Yang SY, Zhang Q, Yang J. Autologous Cord Blood Mononuclear Cells Modulate Immunity and the Microbiota in Very Preterm Twins: A Randomized Trial. Stem Cell Rev Rep. 2026 Jul;22(5):2511-2527. doi: 10.1007/s12015-026-11140-6. Epub 2026 Apr 28.
• Zhuxiao R, Ruoyu H, Liling Y, Xuejun R, Chunhui Y, Wanfen R, Zhifeng C, Yiheng D, Qi Z, Wei W, Zhipeng L, Jingjun P, Qigai Y, Jie Y. Autologous cord blood mononuclear cell infusion for the prevention of bronchopulmonary dysplasia in very preterm monozygotic twins: A study protocol for a randomized, placebo-controlled, double-blinded multicenter trial. Front Pediatr. 2022 Dec 9;10:884366. doi: 10.3389/fped.2022.884366. eCollection 2022.

Drugs

Indications

No indication recorded.