In Hospital IM Naltrexone: A Pilot Study

Summary

This is a study in-hospital administration of injectable naltrexone vs. oral naltrexone. This is a pilot study to assess provider's and patient's acceptability to be randomized to oral vs. injectable naltrexone among hospitalized adults with alcohol use disorder.

Timeline

Start

2022-03

Primary completion

2022-12

Completion

2023-06

Publications

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• Results Kirchoff RW, Mohammed NM, McHugh J, Markota M, Kingsley T, Leung J, Burton MC, Chaudhary R. Naltrexone Initiation in the Inpatient Setting for Alcohol Use Disorder: A Systematic Review of Clinical Outcomes. Mayo Clin Proc Innov Qual Outcomes. 2021 Apr 8;5(2):495-501. doi: 10.1016/j.mayocpiqo.2021.01.013. eCollection 2021 Apr.
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• Results Johnson BA. Naltrexone long-acting formulation in the treatment of alcohol dependence. Ther Clin Risk Manag. 2007 Oct;3(5):741-9.
• Results Murphy CE 4th, Wang RC, Montoy JC, Whittaker E, Raven M. Effect of extended-release naltrexone on alcohol consumption: a systematic review and meta-analysis. Addiction. 2022 Feb;117(2):271-281. doi: 10.1111/add.15572. Epub 2021 Jun 28.
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• Results Financing CDoHCPa. Colorado Hospital Transformation Program. Colorado Office State Web Portal. https://hcpf.colorado.gov/colorado-hospital-transformation-program. Published 2021. Accessed September 16, 2021
• Results Calcaterra SL, McBeth L, Keniston AM, Burden M. The Development and Implementation of a Hospitalist-Directed Addiction Medicine Consultation Service to Address a Treatment Gap. J Gen Intern Med. 2022 Apr;37(5):1065-1072. doi: 10.1007/s11606-021-06849-8. Epub 2021 May 19.
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• Results Alkermes. Alkermes Hospital Inpatient Free Trail Program. Alkermes. https://www.alkermeshospitalprogram.com/. Published 2021. Accessed September 16, 2021.
• Results Weiner BJ, Lewis CC, Stanick C, Powell BJ, Dorsey CN, Clary AS, Boynton MH, Halko H. Psychometric assessment of three newly developed implementation outcome measures. Implement Sci. 2017 Aug 29;12(1):108. doi: 10.1186/s13012-017-0635-3.
• Results Weiner BJ, Lewis, C. C., Stanick, C., Powell, B. J., Dorsey, C. N., Clary, A. S., Boynton, M. H., & Halko, H. Acceptability of Intervention Measure (AIM), Intervention Appropriateness Measure (IAM), & Feasibility of Intervention Measure. Frank Porter Graham Child Development Institute;2017.
• Results Compass HD. Health Data Compass. https://pub.healthdatacompass.org/data-delivery-services/health-data-compass-resources. Published 2019. Accessed September 14, 2021
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• Results McLellan AT, Kushner H, Metzger D, Peters R, Smith I, Grissom G, Pettinati H, Argeriou M. The Fifth Edition of the Addiction Severity Index. J Subst Abuse Treat. 1992;9(3):199-213. doi: 10.1016/0740-5472(92)90062-s.
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• Results Cervantes L, Tuot D, Raghavan R, Linas S, Zoucha J, Sweeney L, Vangala C, Hull M, Camacho M, Keniston A, McCulloch CE, Grubbs V, Kendrick J, Powe NR. Association of Emergency-Only vs Standard Hemodialysis With Mortality and Health Care Use Among Undocumented Immigrants With End-stage Renal Disease. JAMA Intern Med. 2018 Feb 1;178(2):188-195. doi: 10.1001/jamainternmed.2017.7039.
• Results Lee EC, Whitehead AL, Jacques RM, Julious SA. The statistical interpretation of pilot trials: should significance thresholds be reconsidered? BMC Med Res Methodol. 2014 Mar 20;14:41. doi: 10.1186/1471-2288-14-41.

Drugs

Indications