drugset / Trial / NCT05090371

A Multicenter Study of Continued Current Therapy vs Transition to Ofatumumab After Neurofilament (NfL) Elevation

NCT05090371

Phase 4 Active not recruiting 136 enrolled Novartis Pharmaceuticals
RandomizedParallel-groupOpen-labelTreatment

Summary

This study will evaluate if relapsing-remitting MS patients that have not had a relapse in the past year would benefit from a switch to ofatumumab versus staying on their continued current therapy. This study will also look at whether an elevated serum neurofilament light (NfL) level predicts enhanced benefit from a switch to ofatumumab.

Timeline

Start
2022-03-02
Primary completion
2027-04-13
Completion
2027-04-13

Drugs

EvaluationDrugModalityDoseRoute
Subject Ofatumumab Monoclonal antibody 20 mg Subcutaneous