drugset / Trial / NCT05092152
Propofol Versus Ketamine for Rapid Sequence Intubation in Critically Ill Patients
RandomizedParallel-groupOpen-labelTreatment
Summary
Rapid-sequence intubation is routinely performed in critically ill patients. It is unclear whether different sedative agents may influence short-term outcomes after intubation, specially hemodynamic stability.
Timeline
- Start
- 2021-10-23
- Primary completion
- 2023-10-31
- Completion
- 2023-12-31
Outcome
Missed primary endpoint
paper mean difference, 6.0 [95% CI - 0.0 to 11.9]; p = 0.050. PMID 41870554 ↗
Publications
- Schmidt RC, Godinho Zampieri F, da Silva Ramos FJ, Santos Cavatoni Serra F, Maccagnan Pinheiro Besen BA, Fonseca Nunes N, Boschetti D, Chohfi Atallah F, Jackiu M, Garcia Melro LM, Nascimento Pontes CD, Vieira Tomotani DY, Petri Damiani L, Rezende de Freitas FG, Ribeiro Machado F; PROMINE Investigators. Propofol versus ketamine in rapid sequence intubation in critically ill patients: a prospective, randomized, controlled trial. Intensive Care Med. 2026 Mar;52(3):476-489. doi: 10.1007/s00134-026-08351-3. Epub 2026 Mar 23.
- Schmidt RC, Zampieri FG, Ramos FJDS, Serra FSC, Damiani LP, Freitas FGR, Machado FR. Prospective, randomized, controlled trial comparing PROpofol versus KetaMINE in rapid sequence intubation in critically ill patients (PROMINE): protocol paper and statistical analysis plan. Crit Care Sci. 2025 Nov 17;37:e20250133. doi: 10.62675/2965-2774.20250133. eCollection 2025.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Esketamine | Other / unclassified | 2 mg/kg | — |
| Comparator | Propofol | Small molecule | 1.5 mg/kg | — |