Effects of Single Dose Tadalafil on Urethral and Anal Closure Function

Summary

The purpose of the trial is to assess the effect of tadalafil compared to placebo (inactive comparator) on the urethral - and anal pressure and on urine flow in healthy females. Further, the purpose of the trial is to evaluate the potential for going forward with studies of tadalafil in patients suffering from urine or fecal incontinence.

Timeline

Start

2021-08-01

Primary completion

2021-12-30

Completion

2022-01-01

Publications

• Christoffersen T, Riis T, Sonne DP, Klarskov N. Single-dose Tadalafil Reduces Opening Urethral Pressure: A Randomized, Double-blind, Placebo-controlled, Crossover Trial in Healthy Women. Int Urogynecol J. 2024 Mar;35(3):723-729. doi: 10.1007/s00192-024-05757-9. Epub 2024 Mar 8.

Drugs

Indications