drugset / Trial / NCT05103501

Salvage Immunotherapy and Chemotherapy in Esophageal Squamous Cell Carcinoma Patients Nonresponding to Initial Neoadjuvant Chemoradiotherapy

NCT05103501 ↗

Phase 2 Unknown 54 enrolled Shanghai Chest Hospital
NaSingle-groupOpen-labelTreatment

Summary

This is an investigator-initiated, single-arm, exploratory clinical study.The study population consisted of esophageal squamous cell carcinoma patients nonresponding to initial neoadjuvant chemoradiotherapy. The purpose of this study was to evaluate the efficacy and safety of immunotherapy combined with chemotherapy in the adjuvant treatment of esophageal squamous cell carcinoma after surgery.

Timeline

Start
2021-12-01
Primary completion
2023-09-30
Completion
2024-09-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Cisplatin Other / unclassified 75 mg/m2 —
Subject Pembrolizumab Monoclonal antibody 200 mg —
Subject fluorouracil Small molecule 600 mg/m2 —