Symptom-driven ICS/LABA Therapy for Patients With Asthma Non-adherent to Daily Maintenance Inhalers

Phase 1/2 Active not recruiting 60 enrolled Washington University School of Medicine National Center for Advancing Translational Sciences (NCATS) · collab National Institutes of Health (NIH) · collab

RandomizedParallel-groupOpen-labelOther

Summary

Inhaler nonadherence is a common problem that has been estimated to account for approximately 60% of all asthma-related hospitalizations. Unfortunately, prior interventions to improve inhaler nonadherence have shown a lack of long-term success. This study proposes to assess the problem of non-adherence using a D\&I research lens while testing a new inhaler approach to potentially ameliorate the detrimental consequences of maintenance inhaler nonadherence.

Timeline

Start: 2021-12-16
Primary completion: 2025-09-30
Completion: 2025-11-30

Publications

Krings JG, Wojcik KM, Chen V, Sekhar TC, Harris K, Zulich A, Sumino K, Brownson R, Lenze E, Castro M. Symptom-driven inhaled corticosteroid/long-acting beta-agonist therapy for adult patients with asthma who are non-adherent to daily maintenance inhalers: a study protocol for a pragmatic randomized controlled trial. Trials. 2022 Dec 5;23(1):975. doi: 10.1186/s13063-022-06916-3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	budesonide/formoterol	Unknown	—	Inhaled

Symptom-driven ICS/LABA Therapy for Patients With Asthma Non-adherent to Daily Maintenance Inhalers

Summary

Timeline

Publications

Drugs

Indications